Cellular and Physiological Effects of Arginine in Seniors

Vance L. Albaugh; Melissa K. Stewart; Adrian Barbul

doi:10.1016/B978-0-12-805376-8.00027-7

Cellular and Physiological Effects of Arginine in Seniors

Vance L. Albaugh, Melissa K. Stewart, Adrian Barbul

Section of Acute and Critical Care Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

Arginine is a conditionally essential amino acid that plays a number of critical roles in human health and disease. Since discovering arginine to be the nitrogen source for nitric oxide, biomedical research has intensely focused on it and its vasodilatory effects. However, other recent work has highlighted not only these potential cardiovascular benefits of arginine and its metabolites but also the advances in the knowledge of arginine biochemistry, organ-organ trafficking, and insights from clinical studies examining its role of arginine as a therapeutic modality in a variety of disease states. These advances, along with a comprehensive review of arginine biochemistry and physiology, are reviewed within this chapter and aim to highlight this robust area of medical research.

Original language	English
Title of host publication	Nutrition and Functional Foods for Healthy Aging
Publisher	Elsevier Inc.
Pages	317-336
Number of pages	20
ISBN (Electronic)	9780128092996
ISBN (Print)	9780128053768
DOIs	https://doi.org/10.1016/B978-0-12-805376-8.00027-7
State	Published - Feb 22 2017

Keywords

Arginase
Arginine
Citrulline
Metabolism
Nitric oxide
Nitric oxide synthase
Nutritional physiology

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10.1016/B978-0-12-805376-8.00027-7

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AU - Stewart, Melissa K.

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AB - Arginine is a conditionally essential amino acid that plays a number of critical roles in human health and disease. Since discovering arginine to be the nitrogen source for nitric oxide, biomedical research has intensely focused on it and its vasodilatory effects. However, other recent work has highlighted not only these potential cardiovascular benefits of arginine and its metabolites but also the advances in the knowledge of arginine biochemistry, organ-organ trafficking, and insights from clinical studies examining its role of arginine as a therapeutic modality in a variety of disease states. These advances, along with a comprehensive review of arginine biochemistry and physiology, are reviewed within this chapter and aim to highlight this robust area of medical research.

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KW - Arginine

KW - Citrulline

KW - Metabolism

KW - Nitric oxide

KW - Nitric oxide synthase

KW - Nutritional physiology

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ER -

Cellular and Physiological Effects of Arginine in Seniors

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Keywords

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