Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans

Lorina G. Baker, Charles A. Specht, Jennifer K. Lodge

Research output: Contribution to journalComment/debate

59 Scopus citations

Abstract

Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosandeficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.

Original languageEnglish
Pages (from-to)1264-1268
Number of pages5
JournalEukaryotic Cell
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2011

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