Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans

Lorina G. Baker; Charles A. Specht; Jennifer K. Lodge

doi:10.1128/EC.05138-11

Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans

Lorina G. Baker, Charles A. Specht, Jennifer K. Lodge

Research output: Contribution to journal › Comment/debate

61 Scopus citations

Abstract

Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosandeficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.

Original language	English
Pages (from-to)	1264-1268
Number of pages	5
Journal	Eukaryotic Cell
Volume	10
Issue number	9
DOIs	https://doi.org/10.1128/EC.05138-11
State	Published - Sep 2011

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abstract = "Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosandeficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.",

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