Abstract

The proper formation and morphogenesis of dendrites is fundamental to the establishment of neural circuits in the brain. Following cell cycle exit and migration, neurons undergo organized stages of dendrite morphogenesis, which include dendritic arbor growth and elaboration followed by retraction and pruning. Although these developmental stages were characterized over a century ago, molecular regulators of dendrite morphogenesis have only recently been defined. In particular, studies in Drosophila and mammalian neurons have identified numerous cell-intrinsic drivers of dendrite morphogenesis that include transcriptional regulators, cytoskeletal and motor proteins, secretory and endocytic pathways, cell cycle-regulated ubiquitin ligases, and components of other signaling cascades. Here, we review cell-intrinsic drivers of dendrite patterning and discuss how the characterization of such crucial regulators advances our understanding of normal brain development and pathogenesis of diverse cognitive disorders.

Original languageEnglish
Pages (from-to)4657-4671
Number of pages15
JournalDevelopment (Cambridge)
Volume140
Issue number23
DOIs
StatePublished - Dec 1 2013

Keywords

  • Cell-intrinsic driver
  • Dendrite development
  • Dendrite morphogenesis
  • Dendrite patterning
  • Transcription factor
  • Ubiquitin ligases

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