Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection

Vilma Decman, Brian J. Laidlaw, Lauren J. DiMenna, Sarah Abdulla, Krystyna Mozdzanowska, Jan Erikson, Hildegund C.J. Ertl, E. John Wherry

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Although previous studies have demonstrated delayed viral clearance and blunted effector T cell responses in aged mice during infection, memory CD8 T cells and especially secondary responses have received less attention. In this study, we show that modest differences in the number of memory CD8 T cells formed in aged versus young animals were associated with altered memory CD8 T cell differentiation. Aged immune mice had increased morbidity and mortality upon secondary viral challenge, suggesting changes in T cell immunity. Indeed, virus-specific memory CD8 T cells from aged mice showed substantially reduced proliferative expansion upon secondary infection using multiple challenge models. In addition, this defect in recall capacity of aged memory CD8 T cells was cell-intrinsic and persisted upon adoptive transfer into young mice. Thus, the poor proliferative potential of memory T cells and altered memory CD8 T cell differentiation could underlie age-related defects in antiviral immunity.

Original languageEnglish
Pages (from-to)5151-5159
Number of pages9
JournalJournal of Immunology
Volume184
Issue number9
DOIs
StatePublished - May 1 2010

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