Cell determination and regulation during development of neuroblasts and neurones in grasshopper embryo

Paul H. Taghert, Chris Q. Doe, Corey S. Goodman

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

The embryonic development of the central nervous system (CNS) involves the generation of an enormous diversity of cellular types arranged and interconnected in a remarkably precise pattern. In each hemisegment of the grasshopper embryo, the ectoderm generates a stereotyped pattern of 30 neuronal precursor cells, called neuroblasts (Fig. 1)1. Each of these stem cells makes a stereotyped contribution of 6-100 progeny to the ∼1,000 different neurones, each cell identifiable according to its unique morphology, physiology and biochemistry. What are the contributions of cell interactions and cell lineage to the generation of this diversity and specificity of identified neurones in the grasshopper CNS? Here we report on cell ablations with a laser microbeam at different stages of development. Our results suggest the importance of cell-cell interactions in the determination of ectodermal cells to become identified neuroblasts2. However, once a neuroblast begins to divide, then cell lineage appears to play an important role in the determination of its stereotyped family of neuronal progeny3. Furthermore, cell-specific interactions continue to play an important role as neurones, according to their mitotic ancestry, recognize and interact with other differentiating neurones in their environment4-6.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalNature
Volume307
Issue number5947
DOIs
StatePublished - Dec 1 1984
Externally publishedYes

Fingerprint Dive into the research topics of 'Cell determination and regulation during development of neuroblasts and neurones in grasshopper embryo'. Together they form a unique fingerprint.

  • Cite this