Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q

Keyphrases

• Apoptotic Cell Death 16%
• Arginine 16%
• Autosomal Dominant 100%
• Blindness 16%
• Cataract 100%
• Cell Death 100%
• Codon 16%
• CRYAA 100%
• CRYAA Gene 16%
• Crystallin Gene 100%
• Cysteine 16%
• Disease Genes 16%
• Exon 1 16%
• Four Generations 16%
• Haplotype Analysis 16%
• Hereditary Cataract 16%
• Intraocular Lens 16%
• Lens Diseases 16%
• Lens Epithelial Cells 16%
• Linkage Analysis 16%
• LOD Score 16%
• Molecular Chaperone 16%
• Multipoint 16%
• Mutant Protein 16%
• Nonconservative 16%
• Novel mutation 100%
• Nuclear Cataract 16%
• Protein Family 33%
• Recombination Fraction 16%
• Sequence Analysis 16%
• Small Heat Shock Protein (sHSP) 33%
• Staurosporine 16%
• Two-point 16%
• Visual Impairment 16%
• α-crystallin 16%
• αA-crystallin 100%

Medicine and Dentistry

• Alpha Crystallin 25%
• Arginine 25%
• Autosomal Dominant Inheritance 100%
• Cataract 100%
• Cell Death 100%
• Chaperone 25%
• Chromosome 21q 100%
• Codon 25%
• Crystallin 100%
• Cysteine 25%
• Diseases 25%
• Epithelial Cell 25%
• Exon 25%
• Genetic Recombination 25%
• Genetic Transfection 25%
• Haplotype 25%
• Lens Disease 25%
• Linkage Analysis 25%
• Missense Mutation 25%
• Mutant Protein 25%
• Programmed Cell Death 25%
• Protein Family 50%
• Protein Sequencing 25%
• Sequence Analysis 25%
• Small Heat Shock Protein 50%
• Staurosporine 25%
• Visual Impairment 25%

Biochemistry, Genetics and Molecular Biology

• Arginine 33%
• Autosomal Dominant Inheritance 100%
• Cell Death 100%
• Chaperone 33%
• Chromosome 21q 100%
• Codon 33%
• Crystallin 100%
• Cysteine 33%
• Exon 33%
• Genetic Recombination 33%
• Haplotype 33%
• Heat Shock Protein 66%
• Linkage Analysis 33%
• Missense Mutation 33%
• Mutant Protein 33%
• Programmed Cell Death 33%
• Protein Family 66%
• Protein Sequencing 33%
• Staurosporine 33%
• Transfection 33%
• Wild Type 33%