Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents

Betty Poon, Kathie Grovit-Ferbas, Sheila A. Stewart, Irvin S.Y. Chen

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

Expression of human immunodeficiency virus-type 1 (HIV-1) Vpr after productive infection of T cells induces cell cycle arrest in the G2 phase of the cell cycle. In the absence of de novo expression, HIV-1 Vpr packaged into virions still induced cell cycle arrest. Naturally noninfectious virus or virus rendered defective for infection by reverse transcriptase or protease inhibitors were capable of inducing Vpr-mediated cell cycle arrest. These results suggest a model whereby both infectious and noninfectious virions in vivo, such as those surrounding follicular dendritic cells, participate in immune suppression.

Original languageEnglish
Pages (from-to)266-269
Number of pages4
JournalScience
Volume281
Issue number5374
DOIs
StatePublished - Jul 10 1998

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