TY - JOUR
T1 - Cell-Based Therapy for Ischemic Heart Disease
T2 - A Clinical Update
AU - Herrmann, Jeremy L.
AU - Abarbanell, Aaron M.
AU - Weil, Brent R.
AU - Wang, Yue
AU - Wang, Meijing
AU - Tan, Jiangning
AU - Meldrum, Daniel R.
N1 - Funding Information:
This work was supported in part by NIH R01 GM070628, NIH R01 HL085595, NIH K99/R00 HL0876077, NIH F32 HL092718, NIH F32 HL092719, and an American Heart Association Grant-in-aid.
PY - 2009/11
Y1 - 2009/11
N2 - Progenitor cell therapy is a promising treatment for ischemic heart disease. Early clinical trials of autologous bone marrow-derived progenitor cell therapy for acute and chronic myocardial ischemia showed modest functional improvements after cell delivery; however, the duration of these benefits remains unclear. Ongoing investigations continue to enhance our understanding of the mechanisms by which progenitor and stem cells function and how their survival and cardioprotective abilities can be improved. This review discusses: (1) relevant progenitor and stem cells in myocardial regenerative therapy, (2) routes of cell delivery to ischemic myocardium, (3) clinical trials investigating bone marrow-derived progenitor cell therapy for myocardial ischemia, and (4) future directions of the field.
AB - Progenitor cell therapy is a promising treatment for ischemic heart disease. Early clinical trials of autologous bone marrow-derived progenitor cell therapy for acute and chronic myocardial ischemia showed modest functional improvements after cell delivery; however, the duration of these benefits remains unclear. Ongoing investigations continue to enhance our understanding of the mechanisms by which progenitor and stem cells function and how their survival and cardioprotective abilities can be improved. This review discusses: (1) relevant progenitor and stem cells in myocardial regenerative therapy, (2) routes of cell delivery to ischemic myocardium, (3) clinical trials investigating bone marrow-derived progenitor cell therapy for myocardial ischemia, and (4) future directions of the field.
UR - http://www.scopus.com/inward/record.url?scp=70449704532&partnerID=8YFLogxK
U2 - 10.1016/j.athoracsur.2009.05.079
DO - 10.1016/j.athoracsur.2009.05.079
M3 - Review article
C2 - 19853156
AN - SCOPUS:70449704532
SN - 0003-4975
VL - 88
SP - 1714
EP - 1722
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 5
ER -