Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives.

Nikolaos Giagtzoglou, Cindy V. Ly, Hugo J. Bellen

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Synapses are asymmetric intercellular junctions that mediate neuronal communication. The number, type, and connectivity patterns of synapses determine the formation, maintenance, and function of neural circuitries. The complexity and specificity of synaptogenesis relies upon modulation of adhesive properties, which regulate contact initiation, synapse formation, maturation, and functional plasticity. Disruption of adhesion may result in structural and functional imbalance that may lead to neurodevelopmental diseases, such as autism, or neurodegeneration, such as Alzheimer's disease. Therefore, understanding the roles of different adhesion protein families in synapse formation is crucial for unraveling the biology of neuronal circuit formation, as well as the pathogenesis of some brain disorders. The present review summarizes some of the knowledge that has been acquired in vertebrate and invertebrate genetic model organisms.

Original languageEnglish
Pages (from-to)a003079
JournalCold Spring Harbor perspectives in biology
Issue number4
StatePublished - Oct 2009


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