Celeganser: Automated analysis of nematode morphology and age

Linfeng Wang, Shu Kong, Zachary Pincus, Charless Fowlkes

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The nematode Caenorhabditis elegans (C. elegans) serves as an important model organism in a wide variety of biological studies. In this paper we introduce a pipeline for automated analysis of C. elegans imagery for the purpose of studying life-span, health-span and the underlying genetic determinants of aging. Our system detects and segments the worm, and predicts body coordinates at each pixel location inside the worm. These coordinates provides dense correspondence across individual animals to allow for meaningful comparative analysis. We show that a model pre-trained to perform body-coordinate regression extracts rich features that can be used to predict the age of individual worms with high accuracy. This lays the ground for future research in quantifying the relation between organs' physiologic and biochemical state, and individual life/health-span.

Original languageEnglish
Title of host publicationProceedings - 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops, CVPRW 2020
PublisherIEEE Computer Society
Pages4164-4173
Number of pages10
ISBN (Electronic)9781728193601
DOIs
StatePublished - Jun 2020
Event2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops, CVPRW 2020 - Virtual, Online, United States
Duration: Jun 14 2020Jun 19 2020

Publication series

NameIEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops
Volume2020-June
ISSN (Print)2160-7508
ISSN (Electronic)2160-7516

Conference

Conference2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops, CVPRW 2020
CountryUnited States
CityVirtual, Online
Period06/14/2006/19/20

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