CD95-Dependent Bystander Lysis Caused by CD4+ T Helper 1 Effectors

Ruduan Wang, Amy M. Rogers, Timothy L. Ratliff, John H. Russell

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


CD95-dependent lysis of target cells by CD4+ cells raises important questions of specificity and its potential role in inflammation. Much of what we know about CD95L-dependent killing is in fact bystander killing because the T cells have been previously activated by pharmacologic reagents. In an effort to better understand its significance in a more physiologic setting, we have examined bystander lysis by Th1 cells stimulated by Ag and APC in a murine model system. We find that bystander lysis is readily stimulated by Mφ APC but not some epithelial lines, even though they themselves are killed in a CD95-dependent process while serving as APC. Bystander activity requires close proximity between the T cell, the APC, and the bystander target because bystanders are not lysed during coculture in Transwells.

Original languageEnglish
Pages (from-to)2961-2968
Number of pages8
JournalJournal of Immunology
Issue number7
StatePublished - Oct 1 1996


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