CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

Patrícia C.C. Neves; Richard A. Rudersdorf; Ricardo Galler; Myrna C. Bonaldo; Marlon Gilsepp Veloso de Santana; Philip A. Mudd; Maurício A. Martins; Eva G. Rakasz; Nancy A. Wilson; David I. Watkins

doi:10.1016/j.vaccine.2010.09.090

CD8⁺ gamma-delta TCR⁺ and CD4⁺ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

Patrícia C.C. Neves
, Richard A. Rudersdorf
, Ricardo Galler
, Myrna C. Bonaldo
, Marlon Gilsepp Veloso de Santana
, Philip A. Mudd
, Maurício A. Martins
, Eva G. Rakasz
, Nancy A. Wilson
, David I. Watkins

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8⁺ and CD4⁺ T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8⁺ gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4⁺ T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.

Original language	English
Pages (from-to)	8183-8188
Number of pages	6
Journal	Vaccine
Volume	28
Issue number	51
DOIs	https://doi.org/10.1016/j.vaccine.2010.09.090
State	Published - Nov 29 2010

Keywords

IFN-γ
Rhesus model
Yellow fever vaccine

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10.1016/j.vaccine.2010.09.090

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Neves, P. C. C., Rudersdorf, R. A., Galler, R., Bonaldo, M. C., Santana, M. G. V. D., Mudd, P. A., Martins, M. A., Rakasz, E. G., Wilson, N. A., & Watkins, D. I. (2010). CD8⁺ gamma-delta TCR⁺ and CD4⁺ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses. Vaccine, 28(51), 8183-8188. https://doi.org/10.1016/j.vaccine.2010.09.090

@article{d9739010cc964e05b85b20cf5cd5c7e3,

title = "CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses",

abstract = "The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8+ and CD4+ T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8+ gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4+ T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.",

keywords = "IFN-γ, Rhesus model, Yellow fever vaccine",

author = "Neves, \{Patr{\'i}cia C.C.\} and Rudersdorf, \{Richard A.\} and Ricardo Galler and Bonaldo, \{Myrna C.\} and Santana, \{Marlon Gilsepp Veloso de\} and Mudd, \{Philip A.\} and Martins, \{Maur{\'i}cio A.\} and Rakasz, \{Eva G.\} and Wilson, \{Nancy A.\} and Watkins, \{David I.\}",

note = "Funding Information: This work was supported by National Institutes of Health grant R01 AI076114 (to D.I.W.) and Grant P51 RR000167 from the National Center for Research Resources , a component of the National Institutes of Health (to the Wisconsin National Primate Research Center). This research was conducted in part at a facility constructed with support from Research Facilities Improvement Program grants RR15459-01 and RR020141-01 .",

year = "2010",

month = nov,

day = "29",

doi = "10.1016/j.vaccine.2010.09.090",

language = "English",

volume = "28",

pages = "8183--8188",

journal = "Vaccine",

issn = "0264-410X",

number = "51",

}

Neves, PCC, Rudersdorf, RA, Galler, R, Bonaldo, MC, Santana, MGVD, Mudd, PA, Martins, MA, Rakasz, EG, Wilson, NA & Watkins, DI 2010, 'CD8⁺ gamma-delta TCR⁺ and CD4⁺ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses', Vaccine, vol. 28, no. 51, pp. 8183-8188. https://doi.org/10.1016/j.vaccine.2010.09.090

CD8⁺ gamma-delta TCR⁺ and CD4⁺ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses. / Neves, Patrícia C.C.; Rudersdorf, Richard A.; Galler, Ricardo et al.
In: Vaccine, Vol. 28, No. 51, 29.11.2010, p. 8183-8188.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

AU - Neves, Patrícia C.C.

AU - Rudersdorf, Richard A.

AU - Galler, Ricardo

AU - Bonaldo, Myrna C.

AU - Santana, Marlon Gilsepp Veloso de

AU - Mudd, Philip A.

AU - Martins, Maurício A.

AU - Rakasz, Eva G.

AU - Wilson, Nancy A.

AU - Watkins, David I.

N1 - Funding Information: This work was supported by National Institutes of Health grant R01 AI076114 (to D.I.W.) and Grant P51 RR000167 from the National Center for Research Resources , a component of the National Institutes of Health (to the Wisconsin National Primate Research Center). This research was conducted in part at a facility constructed with support from Research Facilities Improvement Program grants RR15459-01 and RR020141-01 .

PY - 2010/11/29

Y1 - 2010/11/29

N2 - The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8+ and CD4+ T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8+ gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4+ T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.

AB - The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8+ and CD4+ T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8+ gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4+ T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.

KW - IFN-γ

KW - Rhesus model

KW - Yellow fever vaccine

UR - https://www.scopus.com/pages/publications/78649680321

U2 - 10.1016/j.vaccine.2010.09.090

DO - 10.1016/j.vaccine.2010.09.090

M3 - Article

C2 - 20939995

AN - SCOPUS:78649680321

SN - 0264-410X

VL - 28

SP - 8183

EP - 8188

JO - Vaccine

JF - Vaccine

IS - 51

ER -

CD8⁺ gamma-delta TCR⁺ and CD4⁺ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

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Keywords

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