TY - JOUR
T1 - CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses
AU - Neves, Patrícia C.C.
AU - Rudersdorf, Richard A.
AU - Galler, Ricardo
AU - Bonaldo, Myrna C.
AU - Santana, Marlon Gilsepp Veloso de
AU - Mudd, Philip A.
AU - Martins, Maurício A.
AU - Rakasz, Eva G.
AU - Wilson, Nancy A.
AU - Watkins, David I.
N1 - Funding Information:
This work was supported by National Institutes of Health grant R01 AI076114 (to D.I.W.) and Grant P51 RR000167 from the National Center for Research Resources , a component of the National Institutes of Health (to the Wisconsin National Primate Research Center). This research was conducted in part at a facility constructed with support from Research Facilities Improvement Program grants RR15459-01 and RR020141-01 .
PY - 2010/11/29
Y1 - 2010/11/29
N2 - The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8+ and CD4+ T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8+ gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4+ T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.
AB - The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8+ and CD4+ T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8+ gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4+ T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.
KW - IFN-γ
KW - Rhesus model
KW - Yellow fever vaccine
UR - http://www.scopus.com/inward/record.url?scp=78649680321&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2010.09.090
DO - 10.1016/j.vaccine.2010.09.090
M3 - Article
C2 - 20939995
AN - SCOPUS:78649680321
SN - 0264-410X
VL - 28
SP - 8183
EP - 8188
JO - Vaccine
JF - Vaccine
IS - 51
ER -