CD8 T cells can protect against an intracellular bacterium in an interferon γ-independent fashion

J. T. Harty, R. D. Schreiber, M. J. Bevan

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Specific T-cell immunity to Listeria monocytogenes is thought to occur through the action of lymphokines which activate phagocytes to ingest and kill microorganisms. Interferon γ (IFN-γ) has been shown to be an effective mediator of this type of macrophage activation in vivo and in vitro. The monoclonal antibody H22.1 efficiently neutralizes endogenous IFN-γ, exacerbates disease in a mouse model of L. monocytogenes infection, and inhibits the in vivo protective activity of a Listeria antigen-specific CD4 T-cell line. In contrast, in vivo protection by Listeria-immune CD8 T cells is not inhibited by the neutralizing anti-IFN-γ monoclonal antibody. These results suggest that CD8 T cells can protect against an intracellular pathogen in an IFN-γ-independent manner.

Original languageEnglish
Pages (from-to)11612-11616
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number23
DOIs
StatePublished - Dec 15 1992

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