TY - JOUR
T1 - CD8 T cell dysfunction during chronic viral infection
AU - Shin, Haina
AU - Wherry, E. John
N1 - Funding Information:
We thank SD Blackburn for helpful discussion. We were able to cite only a fraction of the relevant literature and apologize to colleagues whose contributions may not have been appropriately acknowledged. EJW is supported by grants from NIH/NIAID (AI071309), the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative, and the Commonwealth Universal Research Enhancement Program, Pennsylvania Department of Health.
PY - 2007/8
Y1 - 2007/8
N2 - Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.
AB - Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.
UR - http://www.scopus.com/inward/record.url?scp=34548050436&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2007.06.004
DO - 10.1016/j.coi.2007.06.004
M3 - Review article
C2 - 17656078
AN - SCOPUS:34548050436
SN - 0952-7915
VL - 19
SP - 408
EP - 415
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 4
ER -