CD8 T cell dysfunction during chronic viral infection

Haina Shin, E. John Wherry

Research output: Contribution to journalReview article

243 Scopus citations

Abstract

Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.

Original languageEnglish
Pages (from-to)408-415
Number of pages8
JournalCurrent Opinion in Immunology
Volume19
Issue number4
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

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