Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.

Original languageEnglish
Pages (from-to)408-415
Number of pages8
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 2007


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