CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection

Megan J. Welch, John R. Teijaro, Hanna A. Lewicki, Marco Colonna, Michael B.A. Oldstone

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

DNAM-1 gene-deficient (-/-) mice take significantly longer to clear an acute and persistent LCMV infection in vivo than DNAM-1 +/+ mice. During acute LCMV priming, at the single cell level, DNAM-1 -/- mice made significantly less cytoplasmic CD8 TNF-α and IL-2 but not IFN-γ than their DNAM-1 +/+ counterparts. Restimulated immune memory CD8 T cells from DNAM-1 -/- and DNAM-1 +/+ mice were equivalent in cytolytic activity against LCMV-infected target cells but DNAM-1 -/- CD8 T cells had significant reductions in TNF-α and IL-2 that were associated on adoptive transfer with the inability to terminate the persistent viral infection.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalVirology
Volume429
Issue number2
DOIs
StatePublished - Aug 1 2012

Keywords

  • Acute LCMV infection
  • DNAM-1 deficiency
  • Persistent LCMV infection
  • T cell defects

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