CD4+ lymphocyte-induced target cell detachment. A model for T cell-mediated lytic and nonlytic inflammatory processes

S. I. Abrams, J. H. Russell

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We have been exploring the hypothesis that T lymphocytes have the potential to mediate immune damage through nonlytic disruption of tissue organization. In this report, we have examined the ability of purified, primary cultures of alloreactive CD4+ T cells to mediate Ag-specific target cell detachment and/or lysis of L cell lines transfected with MHC class II determinants. Using this model, we demonstrate that: 1) MHC class II-specific CD4+ T cells can cause detachment as a distinct event of the E:T interaction, although the pathways or mechanisms involved appear to be different from those utilized by MHC class I-specific CD8+ T cells; 2) detachment and lysis by CD4+ T cells are distinct activities that involve different functional requirements; 3) CD4+ T cell-induced detachment is initiated by direct cell-cell interaction, independent of TNF-α/β; 4) CD4+ T cell-mediated lysis can be accomplished by TNF-α/β-dependent and independent pathways; and 5) the nature of a particular target cell response to alloreactive CD4+ T cell attack reflects its intrinsic susceptibility to one or more potential effector mechanisms.

Original languageEnglish
Pages (from-to)405-413
Number of pages9
JournalJournal of Immunology
Volume146
Issue number2
StatePublished - Jan 1 1991

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