CD45 protein tyrosine phosphatase: Determination of minimal peptide length for substrate recognition and synthesis of some tyrosine-based electrophiles as potential active-site directed irreversible inhibitors

Mark Bobko, Henry R. Wolfe, Ashis Saha, Roland E. Dolle, Diana K. Fisher, Terry J. Higgins

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Using fyn PTK as a template, a series of phosphopeptides 1-11 spanning in length from 1-14 amino acids was prepared. Kinetic evaluation of 1-11 suggest that CD45 does not have a strong preference for its N- or C-terminal amino acids and that extended phosphopeptides are not required for efficient substrate turnover.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number4
DOIs
StatePublished - Feb 16 1995
Externally publishedYes

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