@article{34c18e1693864f02b36693a768681ceb,
title = "CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation",
abstract = "Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.",
keywords = "Adenovirus, CD40 ligation, CML, Dendritic cell, GM-CSF, Immunotherapy",
author = "Stam, {A. G.M.} and Santegoets, {S. J.A.M.} and Westers, {T. M.} and Sombroek, {C. C.} and Janssen, {J. J.W.M.} and Tillman, {B. W.} and {Van De Loosdrecht}, {A. A.} and Pinedo, {H. M.} and Curiel, {D. T.} and Ossenkoppele, {G. J.} and Scheper, {R. J.} and {De Gruijl}, {T. D.}",
note = "Funding Information: We acknowledge Bijan Moshaver for excellent technical assistance. This work was supported by the Netherlands organization for scientific research (NWO) fellowship 901-10-116 (TDG) and by grants from the National Institute of Health (R01 HL67962, P50 CA89019, R01 CA86881, U19 DK57958) (DTC).",
year = "2003",
month = oct,
day = "6",
doi = "10.1038/sj.bjc.6601225",
language = "English",
volume = "89",
pages = "1162--1165",
journal = "British Journal of Cancer",
issn = "0007-0920",
number = "7",
}