CD3-dependent lymphocyte activation by human T cell leukaemia virus type I-producing T cells

J. T. Kimata, F. H. Wong, L. Ratner

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Human T cell leukaemia virus type I-(HTLV-I) transformed cells are capable of stimulating the proliferation of normal T lymphocytes, or stimulating interleukin 2 expression in Jurkat T lymphoid cells. This effect is mediated by the CD2/lymphocyte function-associated antigen 3 (LFA-3) adhesion/signalling pathway. The current work demonstrates that CD3 is also required for this effect, suggesting that the T cell receptor (TCR)/CD3 complex is mediating this effect. However, this effect does not appear to be due to a superantigen since no change in TCR expression was found after HTLV-I-mediated proliferation, nor was proliferation inhibited by an antibody against the specific TCR expressed on Jurkat cells (TCR Vβ8).

Original languageEnglish
Pages (from-to)2433-2437
Number of pages5
JournalJournal of General Virology
Volume75
Issue number9
DOIs
StatePublished - Jan 1 1994

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