CD2-associated protein and the kidney

Andrey S. Shaw, Jeffrey H. Miner

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

During the past 3 years there have been significant advances in our understanding of the biology of the glomerular podocyte. In particular, two proteins, CD2-associated protein and nephrin, have been identified as critical podocyte proteins that are both required for normal glomerular filtration. In addition to supporting the idea that the slit diaphragm plays a crucial role in glomerular function, these results suggest novel insights into the pathogenesis of glomerular diseases. The present review addresses these recent advances and discusses the implications of the findings.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalCurrent Opinion in Nephrology and Hypertension
Volume10
Issue number1
DOIs
StatePublished - 2001

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