TY - JOUR
T1 - CCR2 imaging in human ST-segment elevation myocardial infarction
AU - Lavine, Kory
AU - Sultan, Deborah
AU - Luehmann, Hannah
AU - Detering, Lisa
AU - Zhang, Xiaohui
AU - Heo, Gyu Seong
AU - Zhang, Xiuli
AU - Hoelscher, Michelle
AU - Harrison, Kitty
AU - Combadière, Christophe
AU - Laforest, Richard
AU - Kreisel, Daniel
AU - Woodard, Pamela
AU - Brody, Steven
AU - Gropler, Robert
AU - Liu, Yongjian
N1 - Funding Information:
K.J.L. is supported by grants from the National Institutes of Health (NIH) (nos. HL161185, HL150891 and HL151078), the Children’s Discovery Institute (no. PM-LI-2019-829), Burroughs Welcome Fund (no. 1014782), Leducq Foundation (no. 20CVD02) and generous gifts through Washington University and Barnes-Jewish Hospital. S.L.B. is supported for these studies by the NIH (no. HL151685) and the Barnes-Jewish Hospital Foundation. Y.L. is supported by grants from the NIH (nos. HL145212, HL150891, HL153436, HL151685 and EB025815).
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2023/10
Y1 - 2023/10
N2 - Among the diverse populations of myeloid cells that reside within the healthy and diseased heart, C-C chemokine receptor type 2 (CCR2) is specifically expressed on inflammatory populations of monocytes and macrophages that contribute to the development and progression of heart failure 1–4. Here, we evaluated a peptide-based imaging probe (64Cu-DOTA-ECL1i) that specifically recognizes CCR2+ monocytes and macrophages for human cardiac imaging. Compared to healthy controls, 64Cu-DOTA-ECL1i heart uptake was increased in individuals after acute myocardial infarction, predominately localized within the infarct area, and was associated with impaired myocardial wall motion. These findings establish the feasibility of molecular imaging of CCR2 expression to visualize inflammatory monocytes and macrophages in the injured human heart.
AB - Among the diverse populations of myeloid cells that reside within the healthy and diseased heart, C-C chemokine receptor type 2 (CCR2) is specifically expressed on inflammatory populations of monocytes and macrophages that contribute to the development and progression of heart failure 1–4. Here, we evaluated a peptide-based imaging probe (64Cu-DOTA-ECL1i) that specifically recognizes CCR2+ monocytes and macrophages for human cardiac imaging. Compared to healthy controls, 64Cu-DOTA-ECL1i heart uptake was increased in individuals after acute myocardial infarction, predominately localized within the infarct area, and was associated with impaired myocardial wall motion. These findings establish the feasibility of molecular imaging of CCR2 expression to visualize inflammatory monocytes and macrophages in the injured human heart.
UR - http://www.scopus.com/inward/record.url?scp=85171649481&partnerID=8YFLogxK
U2 - 10.1038/s44161-023-00335-6
DO - 10.1038/s44161-023-00335-6
M3 - Article
AN - SCOPUS:85171649481
SN - 2731-0590
VL - 2
SP - 874
EP - 880
JO - Nature Cardiovascular Research
JF - Nature Cardiovascular Research
IS - 10
ER -