CCL3 promotes germinal center B cells sampling by follicular regulatory T cells in murine lymph nodes

Zachary L. Benet, Matangi Marthi, Fang Ke, Rita Wu, Jackson S. Turner, Jahan B. Gabayre, Michael I. Ivanitskiy, Sahil S. Sethi, Irina L. Grigorova

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells ex vivo. Two-photon imaging revealed that B cells-intrinsic production of CCL3 promotes their probing by follicular regulatory T cells (Tfr) within GCs of murine lymph nodes. Overall this study suggests that CCL3 facilitates direct interactions of foreign antigen-specific GC B cells and their negative regulation with Tfr cells in vivo.

Original languageEnglish
Article number2044
JournalFrontiers in immunology
Volume9
Issue numberSEP
DOIs
StatePublished - Sep 13 2018

Keywords

  • 2-photon imaging
  • CCL3/MIP1-alpha
  • Follicular helper T cells
  • Follicular regulatory T cells (Tfr)
  • Germinal centers

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