CCK receptors and human neurological disease

Sally E. Hays, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Cholecystokinin (CCK) receptor binding was measured in postmortem brain tissue of patients with Alzheimer's dementia, Huntington's chorea, and neurologically healthy matched controls. CCK binding was significantly reduced in the basal ganglia and cerebral cortex of Huntington's patients, but was normal in the temporal and cingulate cortex of patients with Alzheimer's disease. These findings indicate that CCK receptor loss is unique to specific neurodegenerative disease(s), and that CCK may be involved in the symptoms of Huntington's disease but is not implicated in the neuropathology of Alzheimer's dementia.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalLife Sciences
Issue number4
StatePublished - Jul 26 1982


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