Caveolin-I, a putative tumour suppressor gene

B. Razani, A. Schlegel, J. Liu, M. P. Lisanti

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Caveolae ('little caves') are plasma membrane specializations of 50-100 nm in diameter, and the caveolins are structural proteins used by cells to form caveolae. We and other investigators have discovered that Caveolae organelles may be important both in normal signal transduction and in the pathogenesis of a number of human diseases, such as cancer. Here we describe the functional roles of the caveolin gene family and summarize the evidence that supports a role for caveolae as mediators of a number of cellular signalling processes, including apoptosis.

Original languageEnglish
Pages (from-to)494-499
Number of pages6
JournalBiochemical Society transactions
Volume29
Issue number4
DOIs
StatePublished - 2001

Keywords

  • Caveolae
  • Cell transformation
  • D7S522/7q31.1
  • Signal

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