Caveolae: From cell biology to animal physiology

Babak Razani, Scott E. Woodman, Michael P. Lisanti

Research output: Contribution to journalReview articlepeer-review

823 Scopus citations

Abstract

Among the membrane compartments of a cell, vesicles known as "caveolae" have long defied functional characterization. However, since the identification of a family of proteins termed "caveolins", that form and reside in caveolae, a better understanding has emerged. It is now clear that caveolae do not merely play a singular role in the cell, but are pleiotropic in nature - serving to modulate many cellular functions. The purpose of this review is to explicate what is known about caveolins/caveolae and highlight growing areas of caveolar research.

Original languageEnglish
Pages (from-to)431-467
Number of pages37
JournalPharmacological Reviews
Volume54
Issue number3
DOIs
StatePublished - Sep 2002

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