Cationic gadolinium chelate for magnetic resonance imaging of cartilaginous defects

Kido Nwe, Ching Hui Huang, Feini Qu, Robert Warden-Rothman, Clare Y. Zhang, Robert L. Mauck, Andrew Tsourkas

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The ability to detect meniscus defects by magnetic resonance arthrography (MRA) can be highly variable. To improve the delineation of fine tears, we synthesized a cationic gadolinium complex, (Gd-DOTA-AM4)2+, that can electrostatically interact with Glycosaminoglycans (GAGs). The complex has a longitudinal relaxivity (r1) of 4.2 mM-1s-1 and is highly stable in serum. Its efficacy in highlighting soft tissue tears was evaluated in comparison to a clinically employed contrast agent (Magnevist) using explants obtained from adult bovine menisci. In all cases, Gd-DOTA-AM4 appeared to improve the ability to detect the soft tissue defect by providing increased signal intensity along the length of the tear. Magnevist shows a strong signal near the liquid-meniscus interface, but much less contrast is observed within the defect at greater depths. This provides initial evidence that cationic contrast agents can be used to improve the diagnostic accuracy of MRA.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalContrast Media and Molecular Imaging
Volume11
Issue number3
DOIs
StatePublished - May 1 2016

Keywords

  • Cationic
  • Chelate
  • DOTA
  • Gadolinium
  • Imaging
  • MRA
  • Magenevist
  • Magnetic resonance arthrography

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