Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain

Karl F. Johnson, Wing Chan, Stuart Kornfeld

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

The signals required for rapid internalization of the bovine cation-dependent mannose 6-phosphate receptor have been localized to two distinct regions of the 67-amino acid cytoplasmic domain. One signal includes phenylalanine 13 and phenylalanine 18, while the other involves tyrosine 45. The former signal is more potent than the latter, but both must be present for the maximal rate of receptor internalization. Each signal shares similarities with the known internalization signals of other recycling receptors.

Original languageEnglish
Pages (from-to)10010-10014
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number24
DOIs
StatePublished - 1990

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