Catheter-related infections: Does the spectrum of microbial causes change over time? A nationwide surveillance study

Niccolò Buetti, Elia Lo Priore, Andrew Atkinson, Andreas F. Widmer, Andreas Kronenberg, Jonas Marschall

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Objectives To estimate the incidence and epidemiology of catheter-related bloodstream infections (CRBSIs) on a national scale by using prospective epidemiological data from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). Design Observational study. Setting National surveillance from 2008 to 2015 of acute hospitals in Switzerland. Participants We included acute Swiss hospitals that sent blood cultures and catheter tip culture results on a regular basis during the entire study period to the ANRESIS database. Outcome measure A catheter-related bloodstream infection (termed 'modified CRBSI', mCRBSI) was defined as isolating the same microorganism with identical antibiogram from ≥1 blood cultures (performed ±7 days around the catheter removal) as the one recovered from the catheter tip. Incidence rates of mCRBSI were calculated per 1000 admissions. Results From 2008 to 2015, the mCRBSI incidence rate decreased from 0.83 to 0.58 episodes/1000 admissions (-6% per year, p<0.001). Coagulase-negative staphylococci, Staphylococcus aureus and fungi all exhibited decreasing trends, while rates of enterococci and Gram-negative bacteria remained stable. Conclusions The overall incidence of mCRBSI in Switzerland is decreasing; however, the incidence of mCRBSI due to Enterococci and Gram-negative micro-organisms did not change over time. These pathogens may grow in importance in catheter-related infections, which would have clinical implications for the choice of empirical treatment.

Original languageEnglish
Article numbere023824
JournalBMJ Open
Volume8
Issue number12
DOIs
StatePublished - Dec 1 2018

Keywords

  • CLABSI
  • CRBSI
  • bloodstream infections
  • catheter infection
  • catheter tip
  • trends

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