Abstract
Cathepsin C (CatC, syn. Dipeptidyl peptidase I) is a lysosomal cysteine proteinase expressed in several tissues including inflammatory cells. This enzyme is important for maintaining multiple cellular functions and for processing immune cell-derived proteases. While mutations in the CatC gene were reported in Papillon-Lefèvre syndrome, a rare autosomal recessive disorder featuring hyperkeratosis and periodontitis, evidence from clinical and preclinical studies points toward pro-inflammatory effects of CatC in various disease processes that are mainly mediated by the activation of neutrophil serine proteinases. Moreover, tumor-promoting effects were ascribed to CatC. The aim of this review is to highlight current knowledge of the CatC as a potential therapeutic target in inflammatory disorders.
Original language | English |
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Pages (from-to) | 175-180 |
Number of pages | 6 |
Journal | Biochimie |
Volume | 216 |
DOIs | |
State | Published - Jan 2024 |
Keywords
- Cathepsin C
- Cathepsin G
- Inflammation
- Neutrophil elastase
- Neutrophil serine proteinase
- Proteinase 3