TY - JOUR
T1 - Cataract Surgery Lowers Intraocular Pressure and Medication Use in the Medication Group of the Ocular Hypertension Treatment Study
AU - Ocular Hypertension Treatment Study Group
AU - Mansberger, Steven L.
AU - Gardiner, Stuart K.
AU - Gordon, Mae
AU - Kass, Michael
AU - Ramulu, Pradeep
N1 - Funding Information:
All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. Funding/Support: The Ocular Hypertension Treatment Study was supported by the National Institutes of Health (Bethesda, Maryland), Grants: UG1 EY025183, UG1 EY025180, UG1 EY025181, and UG1 EY025182. S.L.M. received support from Good Samaritan Foundation (Portland, Oregon), and S.K.G. from Good Samaritan Foundation (Portland, Oregon). Financial Disclosures: S.L.M.: Thea (C), Allergan/Abbvie (R), Nicox (C,S); S.K.G.: Heidelberg (equipment); M.G.: No financial disclosures; M.K.: Smatlens (Consulting): P.R.: Ivantis Inc (C); W. L.: Gore (C), Perfuse Therapeutics (C), Heru, Inc (C). All authors attest that they meet the current ICMJE criteria for authorship.
Funding Information:
All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. Funding/Support: The Ocular Hypertension Treatment Study was supported by the National Institutes of Health (Bethesda, Maryland), Grants: UG1 EY025183, UG1 EY025180, UG1 EY025181, and UG1 EY025182. S.L.M. received support from Good Samaritan Foundation (Portland, Oregon), and S.K.G. from Good Samaritan Foundation (Portland, Oregon). Financial Disclosures: S.L.M.: Thea (C), Allergan/Abbvie (R), Nicox (C,S); S.K.G.: Heidelberg (equipment); M.G.: No financial disclosures; M.K.: Smatlens (Consulting): P.R.: Ivantis Inc (C); W. L.: Gore (C), Perfuse Therapeutics (C), Heru, Inc (C). All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/4
Y1 - 2022/4
N2 - Purpose: To determine the change in intraocular pressure (IOP) and ocular hypotensive medication use after cataract extraction in the Medication Group of the Ocular Hypertension Treatment Study. Design: Secondary analysis of randomized clinical trial data. Methods: We included 92 participants (n = 149 eyes) of the Medication Group of the Ocular Hypertension Treatment Study who underwent cataract surgery in at least 1 eye during the study and 531 participants (n = 1004 eyes) of the Medication Group who did not undergo cataract surgery. We defined the “split date” as the first study visit that cataract surgery was reported for the cataract surgery group and the 15th visit in the control group to equalize the median number of visits. We then compared the 2 groups at visits relative to this split date. Main outcome measures: Difference in preoperative and postoperative IOP, and number of classes of ocular hypotensive medications between the cataract and control group over a 72-month period. Results: Cataract surgery significantly decreased the number of ocular hypotensive medications at all postoperative visits (mean, −0.4 medications; P ≤ .005) through the 48-month postoperative visit when compared with the control group. At the split date, approximately 23% of eyes were medication free and 41% had a reduced medication burden. Cataract surgery resulted in a decrease in IOP (P < .001), but the difference in IOP between the groups reduced over time and became nonsignificant after 12 months. Conclusions: Cataract surgery in patients with ocular hypertension produced sustained reductions in the average number of ocular hypotensive medications and transient reductions in IOP.
AB - Purpose: To determine the change in intraocular pressure (IOP) and ocular hypotensive medication use after cataract extraction in the Medication Group of the Ocular Hypertension Treatment Study. Design: Secondary analysis of randomized clinical trial data. Methods: We included 92 participants (n = 149 eyes) of the Medication Group of the Ocular Hypertension Treatment Study who underwent cataract surgery in at least 1 eye during the study and 531 participants (n = 1004 eyes) of the Medication Group who did not undergo cataract surgery. We defined the “split date” as the first study visit that cataract surgery was reported for the cataract surgery group and the 15th visit in the control group to equalize the median number of visits. We then compared the 2 groups at visits relative to this split date. Main outcome measures: Difference in preoperative and postoperative IOP, and number of classes of ocular hypotensive medications between the cataract and control group over a 72-month period. Results: Cataract surgery significantly decreased the number of ocular hypotensive medications at all postoperative visits (mean, −0.4 medications; P ≤ .005) through the 48-month postoperative visit when compared with the control group. At the split date, approximately 23% of eyes were medication free and 41% had a reduced medication burden. Cataract surgery resulted in a decrease in IOP (P < .001), but the difference in IOP between the groups reduced over time and became nonsignificant after 12 months. Conclusions: Cataract surgery in patients with ocular hypertension produced sustained reductions in the average number of ocular hypotensive medications and transient reductions in IOP.
UR - http://www.scopus.com/inward/record.url?scp=85121757280&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2021.07.008
DO - 10.1016/j.ajo.2021.07.008
M3 - Article
C2 - 34280363
AN - SCOPUS:85121757280
SN - 0002-9394
VL - 236
SP - 53
EP - 62
JO - American journal of ophthalmology
JF - American journal of ophthalmology
ER -