TY - JOUR
T1 - Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases
AU - Schwab, Claudia
AU - Demaggio, Anthony J.
AU - Ghoshal, Nupur
AU - Binder, Lester I.
AU - Kuret, Jeff
AU - McGeer, Patrick L.
N1 - Funding Information:
This work was supported by grants to L.I.B., N.G., and J.K. from the National Institutes of Health (AG09466; AG14452; GM56292) and the Alzheimer’s Association (RG2-96-076).
Funding Information:
We thank Dr P. Davies for his gift of the Alz50 antibody and Joane Sunahara for technical assistance. This work was supported by grants from the Parkinson Foundation of Canada, the Alzheimer Society of British Columbia, and the Jack Brown and Family A.D. Research Fund, as well as donations from individual British Columbians.
PY - 2000/7
Y1 - 2000/7
N2 - The distribution of casein kinase 1 δ (Ckiδ) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Ckiδ was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and 'skein'-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Ckiδ and its apparent substrate tau suggests a function for Ckiδ in the abnormal processing of tau. (C) 2000 Elsevier Science Inc.
AB - The distribution of casein kinase 1 δ (Ckiδ) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Ckiδ was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and 'skein'-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Ckiδ and its apparent substrate tau suggests a function for Ckiδ in the abnormal processing of tau. (C) 2000 Elsevier Science Inc.
KW - Alzheimer's disease
KW - Casein kinase 1 delta
KW - Granulovacuolar bodies
KW - Immunocytochemistry
KW - Lewy bodies
KW - Neurofibrillary and glial tangles
KW - Pallido-ponto-nigral degeneration
KW - Parkinson's disease
KW - Parkinsonism dementia complex of Guam
KW - Pick's disease
UR - http://www.scopus.com/inward/record.url?scp=0034622242&partnerID=8YFLogxK
U2 - 10.1016/S0197-4580(00)00110-X
DO - 10.1016/S0197-4580(00)00110-X
M3 - Article
C2 - 10924763
AN - SCOPUS:0034622242
SN - 0197-4580
VL - 21
SP - 503
EP - 510
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 4
ER -