TY - JOUR
T1 - Case Report
T2 - Supernormal Vascular Aging in Leningrad Siege Survivors
AU - Rotar, Oxana
AU - Boyarinova, Maria
AU - Moguchaya, Ekaterina
AU - Tolkunova, Kristina
AU - Kolosov, Nikita
AU - Rezapova, Valeriia
AU - Freylikhman, Olga
AU - Usoltsev, Dmitrii
AU - Melnik, Olesya
AU - Sergushichev, Alexey
AU - Solntsev, Vladislav
AU - Kostareva, Anna
AU - Dubinina, Elena
AU - Voortman, Trudy
AU - Stevens, Christine
AU - Daly, Mark J.
AU - Konradi, Alexandra
AU - Shlyakhto, Evgeny
AU - Artomov, Mykyta
N1 - Publisher Copyright:
Copyright © 2022 Rotar, Boyarinova, Moguchaya, Tolkunova, Kolosov, Rezapova, Freylikhman, Usoltsev, Melnik, Sergushichev, Solntsev, Kostareva, Dubinina, Voortman, Stevens, Daly, Konradi, Shlyakhto and Artomov.
PY - 2022/5/23
Y1 - 2022/5/23
N2 - Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.
AB - Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.
KW - aging
KW - deep phenotyping
KW - pulse wave velocity (PWV)
KW - starvation
KW - supernormal vascular aging
UR - http://www.scopus.com/inward/record.url?scp=85138463996&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2022.843439
DO - 10.3389/fcvm.2022.843439
M3 - Article
AN - SCOPUS:85138463996
SN - 2297-055X
VL - 9
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 843439
ER -