TY - JOUR
T1 - Case report
T2 - Peptide receptor radioligand therapy in metastatic pediatric neuroendocrine tumors
AU - Hlongwa, Khanyisile
AU - Kolade, Olumayowa
AU - Alnabulsi, Abdulilah
AU - Steyn, Rachelle
AU - Brink, Anita
AU - Prasad, Vikas
AU - More, Stuart
N1 - Publisher Copyright:
2023 Hlongwa, Kolade, Alnabulsi, Steyn, Brink, Prasad and More.
PY - 2023
Y1 - 2023
N2 - Neuroendocrine tumors (NETs) are not commonly diagnosed in children. Metastatic NETs tend to have poor outcomes, and this is seen in adult and pediatric populations. The role of somatostatin receptor imaging using [68Ga]Ga-DOTA-TATE for imaging and peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE in children is currently not well established. The guidelines for treating pediatric neuroendocrine tumors are still lacking. Extensive trials have been conducted in adult patients and have demonstrated improved survival in metastatic NETs with PRRT using [177Lu]Lu-DOTA-TATE. We present two pediatric patients with metastatic NETs who were imaged with [68Ga]Ga-DOTA-TATE PET/CT and treated with [177Lu]Lu-DOTA-TATE therapy.
AB - Neuroendocrine tumors (NETs) are not commonly diagnosed in children. Metastatic NETs tend to have poor outcomes, and this is seen in adult and pediatric populations. The role of somatostatin receptor imaging using [68Ga]Ga-DOTA-TATE for imaging and peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE in children is currently not well established. The guidelines for treating pediatric neuroendocrine tumors are still lacking. Extensive trials have been conducted in adult patients and have demonstrated improved survival in metastatic NETs with PRRT using [177Lu]Lu-DOTA-TATE. We present two pediatric patients with metastatic NETs who were imaged with [68Ga]Ga-DOTA-TATE PET/CT and treated with [177Lu]Lu-DOTA-TATE therapy.
KW - DOTA-TATE
KW - PRRT
KW - neuroendocrine tumor
KW - pediatrics
KW - theranostics (combined therapeutic and diagnostic technology)
UR - http://www.scopus.com/inward/record.url?scp=85183603663&partnerID=8YFLogxK
U2 - 10.3389/fnume.2023.1193880
DO - 10.3389/fnume.2023.1193880
M3 - Article
C2 - 39355026
AN - SCOPUS:85183603663
SN - 2673-8880
VL - 3
JO - Frontiers in Nuclear Medicine
JF - Frontiers in Nuclear Medicine
M1 - 1193880
ER -