CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond

Ze Nan L. Chang; Yvonne Y. Chen

doi:10.1016/j.molmed.2017.03.002

CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond

Ze Nan L. Chang, Yvonne Y. Chen

Division of Gastroenterology

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune diseases. Here, we review current understanding of the molecular properties of CARs, how this knowledge informs the rational design and characterization of novel receptors, the successes and shortcomings of CAR-T cells in the clinic, and emerging solutions for the continued improvement of CAR-T cell therapy.

Original language	English
Pages (from-to)	430-450
Number of pages	21
Journal	Trends in Molecular Medicine
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.molmed.2017.03.002
State	Published - May 2017

Keywords

adoptive T-cell therapy
chimeric antigen receptor (CAR)
immunotherapy
protein engineering
synthetic biology

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10.1016/j.molmed.2017.03.002

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title = "CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond",

abstract = "Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune diseases. Here, we review current understanding of the molecular properties of CARs, how this knowledge informs the rational design and characterization of novel receptors, the successes and shortcomings of CAR-T cells in the clinic, and emerging solutions for the continued improvement of CAR-T cell therapy.",

keywords = "adoptive T-cell therapy, chimeric antigen receptor (CAR), immunotherapy, protein engineering, synthetic biology",

author = "Chang, {Ze Nan L.} and Chen, {Yvonne Y.}",

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AB - Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune diseases. Here, we review current understanding of the molecular properties of CARs, how this knowledge informs the rational design and characterization of novel receptors, the successes and shortcomings of CAR-T cells in the clinic, and emerging solutions for the continued improvement of CAR-T cell therapy.

KW - adoptive T-cell therapy

KW - chimeric antigen receptor (CAR)

KW - immunotherapy

KW - protein engineering

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CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond

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Keywords

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