@article{341fe7889c794264a40c399304ccce62,
title = "Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study",
abstract = "We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990-1992) and PET scans (2012-2014) were studied. Participants in the highest (versus lowest) cIMT tertile had 2.17 times the odds of elevated Aβ (95% CI: 1.15-4.11), after demographic and APOE ϵ4 adjustments. An interaction with APOE ϵ4 was observed (p = 0.02). Greater cIMT was associated with elevated Aβ independent of vascular risk factors among those with ≥1 APOE ϵ4 allele, but not in noncarriers. In this cohort, higher cIMT was associated with Aβ deposition 22 years later, particularly among APOE ϵ4 carriers.",
keywords = "Alzheimer's disease, amyloid-β, carotid intima-media thickness, carotid ultrasound, florbetapir PET",
author = "Wendy Wang and Gottesman, {Rebecca F.} and Meyer, {Michelle L.} and Hughes, {Timothy M.} and Sullivan, {Kevin J.} and Wong, {Dean F.} and Kamakshi Lakshminarayan and Lutsey, {Pamela L.}",
note = "Funding Information: The ARIC Study is carried out as a collaborative study supported by NHLBI contracts (HHSN26820 1700001I, HHSN268201700002I, HHSN2682017 00003I, HHSN268201700005I, HHSN2682017000 04I). Neurocognitive data is collected by U01 2U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917 from the NIH (NHLBI, NINDS, NIA and NIDCD). Brain MRI examinations are funded by the NHLBI (R01-HL70825). The ARIC-PET study is funded by the NIA (R01AG040282). Avid Radiopharmaceuticals provided the florbetapir isotope for the study but had no role in the study design or interpretation of results. This work was also supported by the NIGMS [T32GM132063 (WW)] and the NHLBI [K24HL159246 (PLL)]. The authors thank ARIC study staff and participants for their important contributions. Publisher Copyright: {\textcopyright} 2022-IOS Press. All rights reserved.",
year = "2022",
doi = "10.3233/JAD-215671",
language = "English",
volume = "88",
pages = "17--22",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
number = "1",
}