Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

Wendy Wang, Rebecca F. Gottesman, Michelle L. Meyer, Timothy M. Hughes, Kevin J. Sullivan, Dean F. Wong, Kamakshi Lakshminarayan, Pamela L. Lutsey

Research output: Contribution to journalArticlepeer-review


We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990-1992) and PET scans (2012-2014) were studied. Participants in the highest (versus lowest) cIMT tertile had 2.17 times the odds of elevated Aβ (95% CI: 1.15-4.11), after demographic and APOE ϵ4 adjustments. An interaction with APOE ϵ4 was observed (p = 0.02). Greater cIMT was associated with elevated Aβ independent of vascular risk factors among those with ≥1 APOE ϵ4 allele, but not in noncarriers. In this cohort, higher cIMT was associated with Aβ deposition 22 years later, particularly among APOE ϵ4 carriers.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalJournal of Alzheimer's Disease
Issue number1
StatePublished - 2022


  • Alzheimer's disease
  • amyloid-β
  • carotid intima-media thickness
  • carotid ultrasound
  • florbetapir PET


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