Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

Wendy Wang; Rebecca F. Gottesman; Michelle L. Meyer; Timothy M. Hughes; Kevin J. Sullivan; Dean F. Wong; Kamakshi Lakshminarayan; Pamela L. Lutsey

doi:10.3233/JAD-215671

Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

Wendy Wang, Rebecca F. Gottesman, Michelle L. Meyer, Timothy M. Hughes, Kevin J. Sullivan, Dean F. Wong, Kamakshi Lakshminarayan, Pamela L. Lutsey

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Abstract

We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990-1992) and PET scans (2012-2014) were studied. Participants in the highest (versus lowest) cIMT tertile had 2.17 times the odds of elevated Aβ (95% CI: 1.15-4.11), after demographic and APOE ϵ4 adjustments. An interaction with APOE ϵ4 was observed (p = 0.02). Greater cIMT was associated with elevated Aβ independent of vascular risk factors among those with ≥1 APOE ϵ4 allele, but not in noncarriers. In this cohort, higher cIMT was associated with Aβ deposition 22 years later, particularly among APOE ϵ4 carriers.

Original language	English
Pages (from-to)	17-22
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	88
Issue number	1
DOIs	https://doi.org/10.3233/JAD-215671
State	Published - 2022

Keywords

Alzheimer's disease
amyloid-β
carotid intima-media thickness
carotid ultrasound
florbetapir PET

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10.3233/JAD-215671

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title = "Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study",

abstract = "We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990-1992) and PET scans (2012-2014) were studied. Participants in the highest (versus lowest) cIMT tertile had 2.17 times the odds of elevated Aβ (95% CI: 1.15-4.11), after demographic and APOE ϵ4 adjustments. An interaction with APOE ϵ4 was observed (p = 0.02). Greater cIMT was associated with elevated Aβ independent of vascular risk factors among those with ≥1 APOE ϵ4 allele, but not in noncarriers. In this cohort, higher cIMT was associated with Aβ deposition 22 years later, particularly among APOE ϵ4 carriers.",

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AU - Gottesman, Rebecca F.

AU - Meyer, Michelle L.

AU - Hughes, Timothy M.

AU - Sullivan, Kevin J.

AU - Wong, Dean F.

AU - Lakshminarayan, Kamakshi

AU - Lutsey, Pamela L.

PY - 2022

Y1 - 2022

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KW - Alzheimer's disease

KW - amyloid-β

KW - carotid intima-media thickness

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KW - florbetapir PET

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Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

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