Cardiovascular sensitivity to epinephrine in the trained and untrained states

Wade H. Martin, Edward F. Coyle, Ali A. Ehsani

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Heart rate (HR), blood pressure (BP) and inotropic responses to acute exercise are partially mediated by sympathetic stimulation. Physical conditioning reduces exercise HR and improves maximal stroke volume and cardiac output. Uncertainty exists regarding the role of altered catecholamine sensitivity in producing these changes in man. In 6 highly trained men, noninvasive methods were used to serially assess the effect of cessation of training on the resting HR, BP and left ventricular contractile function in response to constant epinephrine infusion. Plasma epinephrine concentration during infusion did not vary with inactivity and was similar to that attained with strenous exercise. Two subjects showed an increase in chronotropic sensitivity to epinephrine and 4 showed no consistent change. Despite a significant decline in exercise capacity and no apparent change in cardiac loading conditions, there was no persistent effect of inactivity on BP or left ventricular function as assessed by echocardiography and systolic time intervals. Therefore, an alteration in sensitivity to epinephrine is unlikely to account for the hemodynamic adaptations to endurance exercise training in healthy men.

Original languageEnglish
Pages (from-to)1326-1330
Number of pages5
JournalThe American journal of cardiology
Issue number10
StatePublished - Dec 1 1984


Dive into the research topics of 'Cardiovascular sensitivity to epinephrine in the trained and untrained states'. Together they form a unique fingerprint.

Cite this