TY - JOUR
T1 - Cardiovascular history and risk of idiopathic Parkinson’s disease
T2 - a cross-sectional observational study
AU - NCER-PD Consortium
AU - Acharya, Shubhra
AU - Lumley, Andrew I.
AU - Devaux, Yvan
AU - Ali, Muhammad
AU - Ramia, Nancy E.
AU - Arena, Giuseppe
AU - Balling, Rudi
AU - Bassis, Michele
AU - Becker, Regina
AU - Boussaad, Ibrahim
AU - Gawron, Piotr
AU - Ghosh, Soumyabrata
AU - Glaab, Enrico
AU - De Lope, Elisa Gómez
AU - Groues, Valentin
AU - Grünewald, Anne
AU - Gu, Wei
AU - Heneka, Michael
AU - Herzinger, Sascha
AU - Lebioda, Jacek Jaroslaw
AU - Jaroz, Yohan
AU - Klopfenstein, Quentin
AU - Landoulsi, Zied
AU - Marques, Tainá M.
AU - Conde, Patricia Martins
AU - May, Patrick
AU - Meisch, Francoise
AU - Nickels, Sarah
AU - Ostaszewski, Marek
AU - Gomes, Clarissa P.C.
AU - Pachchek, Sinthuja
AU - Rauschenberger, Armin
AU - Rawal, Rajesh
AU - Bobbili, Dheeraj Reddy
AU - Roomp, Kirsten
AU - Rosety, Isabel
AU - Sapienza, Stefano
AU - Satagopam, Venkata
AU - Schmitz, Sabine
AU - Schneider, Reinhard
AU - Schwamborn, Jens
AU - Soboleva, Ekaterina
AU - Loo, Rebecca Ting Jiin
AU - Trefois, Christophe
AU - Vega, Carlos
AU - Vyas, Maharshi
AU - Wilmes, Paul
AU - Wollscheid-Lengeling, Evi
AU - Klucken, Jochen
AU - Krüger, Rejko
AU - Pauly, Claire
AU - Pavelka, Lukas
AU - Hansen, Linda
AU - van Cutsem, Gilles
AU - Acharya, Geeta
AU - Aguayo, Gloria
AU - Alexandre, Myriam
AU - Ammerlann, Wim
AU - Beaumont, Katy
AU - Bellora, Camille
AU - Calmes, Jessica
AU - Castillo, Lorieza
AU - Contesotto, Gessica
AU - Esteves, Daniela
AU - Fagherazzi, Guy
AU - Ferrand, Jean Yves
AU - Giraitis, Marijus
AU - Graas, Jérôme
AU - Hammot, Gaël
AU - Hanff, Anne Marie
AU - Henry, Estelle
AU - Heymann, Michael
AU - Hundt, Alexander
AU - Jónsdóttir, Sonja
AU - Lambert, Pauline
AU - Lorentz, Victoria
AU - Lupu, Paula Cristina
AU - Marques, Guilherme
AU - Mcintyre, Deborah
AU - Mediouni, Chouaib
AU - Menster, Myriam
AU - Minelli, Maura
AU - Nehrbass, Ulf
AU - Noor, Fozia
AU - Perquin, Magali
AU - Lima, Rosalina Ramos
AU - Rosales, Eduardo
AU - Sandt, Estelle
AU - Schmitt, Margaux
AU - Sharify, Amir
AU - Sokolowska, Kate
AU - Thien, Hermann
AU - Trouet, Johanna
AU - Tsurkalenko, Olena
AU - Vaillant, Michel
AU - Valenti, Mesele
AU - Berchem, Guy
AU - Diederich, Nico
AU - Boas, Liliana Vilas
AU - Zelimkhanov, Gelani
AU - Longhino, Laura
AU - Nati, Romain
AU - Nicolai, Beatrice
AU - Thiry, Elodie
AU - Mühlschlegel, Friedrich
AU - Bisdorff, Alexandre
AU - Dondelinger, Rene
AU - Herbrink, Sylvia
AU - Lentz, Roseline
AU - Hu, Michele
AU - Wade-Martins, Richard
AU - Mackay, Clare
AU - Berg, Daniela
AU - Brockmann, Kathrin
AU - Gasser, Thomas
AU - Liepelt, Inga
AU - Mollenhauer, Brit
AU - Marcus, Katrin
AU - Liszka, Robert
AU - Maetzler, Walter
AU - Graziano, Mariella
AU - Jacoby, Nadine
AU - Nicolay, Jean Paul
AU - Pauly, Laure
AU - Mittelbronn, Michel
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Background: Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the development of severe autonomic dysfunction. One of the initial indicators of PD is the appearance of cardiovascular dysautonomia. As such, it is vital to monitor and manage cardiovascular health of individuals with PD, as it may have clinical implications in the development of commonly recognized motor and non-motor aspects of the disease. To study the association of history of cardiovascular disease (CVD) with occurrence and severity of PD, here, we lend data on the association of CVD history with the frequency and the occurrence of idiopathic PD (iPD) using data from the Luxembourg Parkinson’s study (iPD n = 676 patients and non-PD n = 874 controls). Results: We report that patients with a history of CVD are at high risk of developing iPD (odds ratio; OR = 1.56, 95% confidence interval; CI 1.09–2.08). This risk is stronger in males and remains significant after adjustment with confounders (OR 1.55, 95% CI 1.05–2.30). This increased susceptibility to iPD is linked to the severity of iPD symptoms mainly the non-motor symptoms of daily living (MDS-UPDRS I) and motor complications (MDS-UPDRS IV) in the affected individuals. Conclusion: Individuals with history of CVD have a high risk of developing severe forms of iPD. This observation suggests that careful monitoring and management of patients with a history of cardiac problems may reduce the burden of iPD.
AB - Background: Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the development of severe autonomic dysfunction. One of the initial indicators of PD is the appearance of cardiovascular dysautonomia. As such, it is vital to monitor and manage cardiovascular health of individuals with PD, as it may have clinical implications in the development of commonly recognized motor and non-motor aspects of the disease. To study the association of history of cardiovascular disease (CVD) with occurrence and severity of PD, here, we lend data on the association of CVD history with the frequency and the occurrence of idiopathic PD (iPD) using data from the Luxembourg Parkinson’s study (iPD n = 676 patients and non-PD n = 874 controls). Results: We report that patients with a history of CVD are at high risk of developing iPD (odds ratio; OR = 1.56, 95% confidence interval; CI 1.09–2.08). This risk is stronger in males and remains significant after adjustment with confounders (OR 1.55, 95% CI 1.05–2.30). This increased susceptibility to iPD is linked to the severity of iPD symptoms mainly the non-motor symptoms of daily living (MDS-UPDRS I) and motor complications (MDS-UPDRS IV) in the affected individuals. Conclusion: Individuals with history of CVD have a high risk of developing severe forms of iPD. This observation suggests that careful monitoring and management of patients with a history of cardiac problems may reduce the burden of iPD.
KW - Cardiovascular health
KW - Comorbidities
KW - Parkinson’s disease
KW - Sex-differences
UR - http://www.scopus.com/inward/record.url?scp=85198059411&partnerID=8YFLogxK
U2 - 10.1186/s12868-024-00875-y
DO - 10.1186/s12868-024-00875-y
M3 - Article
C2 - 38977971
AN - SCOPUS:85198059411
SN - 1471-2202
VL - 25
JO - BMC Neuroscience
JF - BMC Neuroscience
IS - 1
M1 - 33
ER -