Cardiorespiratory Stability in Critically Ill Preterm Infants following Dexmedetomidine Initiation

Brynne A. Sullivan, Paige Howard, Hayley Kendrick, Brandy Zeller, Christopher McPherson, Zachary A. Vesoulis

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study aimed to evaluate cardiorespiratory status in preterm infants receiving dexmedetomidine using high-resolution physiologic data. Study Design: We analyzed preterm infants with continuous heart rate (HR) and oxygen saturation (SpO 2) data for 24 hours preceding and 48 hours following dexmedetomidine initiation. Invasive arterial blood pressure (ABP), when available, was analyzed. Results: In 100 infants with a mean gestational age of 28 weeks and high baseline illness severity, mean HR decreased from 152 to 141 beats per minute while mean SpO 2 increased from 91 to 93% in the 48 hours after dexmedetomidine initiation (p < 0.01). In 57 infants with continuous ABP monitoring, mean ABP increased from 40 to 42 mm Hg (p = 0.01). Vasoactive-inotropic support increased before and after initiation. Conclusion: We observed cardiorespiratory changes in critically ill preterm infants following dexmedetomidine initiation; mean HR decreased and mean SpO 2 increased in the 48 hours after initiation. In a subset, mean ABP increased along with vasoactive-inotropic support.

Original languageEnglish
JournalAmerican journal of perinatology
DOIs
StateAccepted/In press - 2024

Keywords

  • arterial blood pressure
  • dexmedetomidine
  • heart rate
  • oxygenation
  • preterm infants

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