Cardiopulmonary bypass in the immature fetus through novel use of a mini-centrifugal pump

John Lombardi, Joseph Sedgwick, Jennifer Schenbeck, Walter Lubbers, Robert E. Ferguson, Aimee Gardner, Jerri L. McNamara, Pirooz Eghtesady

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The concept that the natural history of certain heart defects could be positively modified through in utero intervention has stimulated extensive research in fetal cardiac intervention and surgery since the early 1980s. Since the management of certain defects would require the use of cardiopulmonary support, extensive studies have been directed toward the application of a variety of perfusion circuits. The unique features of the fetal patient have directed the focus of many of these designs toward miniaturization of components and minimization of prime volume. Large extracorporeal surface contact areas and prime volumes have been identified as potential contributors to a frequently observed placental dysfunction following fetal cardiopulmonary bypass (CPB). We set out to develop mean of CPB using a centrifugal micro-system that would not require supplemental prime volume. We describe the unique application of an adult right heart assist device, primarily used for 'off-pump' coronary revascularization for fetal cardiopulmonary support. Finally, while previous fetal experiments have used late-gestation mature fetuses, we studied more immature fetuses of mid-gestation, relevant to current clinical attempts in fetal therapy.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalPerfusion
Volume21
Issue number3
DOIs
StatePublished - Jun 29 2006
Externally publishedYes

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    Lombardi, J., Sedgwick, J., Schenbeck, J., Lubbers, W., Ferguson, R. E., Gardner, A., McNamara, J. L., & Eghtesady, P. (2006). Cardiopulmonary bypass in the immature fetus through novel use of a mini-centrifugal pump. Perfusion, 21(3), 185-191. https://doi.org/10.1191/0267659105pf862oa