Cardiac 17O MRI: Toward direct quantification of myocardial oxygen consumption

Kyle S. McCommis, Xiang He, Dana R. Abendschein, Pradeep M. Gupte, Robert J. Gropler, Jie Zheng

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A new 17O-labeled blood contrast agent was injected intravenously in control dogs. Electrocardiogram (ECG)-triggered myocardial T imaging was performed to obtain spin-locking T -weighted myocardial signals for the detection of resultant metabolite H217O water in the heart. Bolus and slow injection methods of various doses of the 17O-labeled and 16O-labeled agents were carried out in order to evaluate the sensitivity of this method and determine the optimal injection method. Bolus injection provided approximately 1% signal reduction, whereas slow injection with larger amount of agent yielded 11.9 ± 0.6% signal reduction. Myocardial oxygen consumption rate was determined by a technique to quantify cerebral oxygenation consumption rate previously developed in 17O brain studies. With either injection method, myocardial oxygen consumption rate at rest was 5.0 - 5.6 μmol/g/min. Therefore, it appears feasible to detect metabolically generated H217O water in vivo in the heart, using the 17O-labeled blood tracer. Myocardial oxygen consumption rate can then be quantified in vivo, which may open new doors for the assessment of myocardial metabolism.

Original languageEnglish
Pages (from-to)1442-1447
Number of pages6
JournalMagnetic resonance in medicine
Volume63
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • MR
  • Metabolic imaging
  • Myocardial oxygenation consumption
  • O
  • T imaging

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