TY - JOUR
T1 - Cardiac sarcolemmal KATP channels
T2 - Latest twists in a questing tale!
AU - Zhang, Haixia
AU - Flagg, Thomas P.
AU - Nichols, Colin G.
PY - 2010/1
Y1 - 2010/1
N2 - Reconstitution of KATP channel activity from coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, as well as the essential roles of Kir6.2 and SUR2 subunits in generating cardiac ventricular KATP. However, despite this extensive body of knowledge, there remain significant holes in our understanding of the physiological role of the cardiac KATP channel, and surprising new findings keep emerging. Recent findings from genetically modified animals include the apparent insensitivity of cardiac sarcolemmal channels to nucleotide levels, and unenvisioned complexities of the subunit make-up of the cardiac channels. This topical review focuses on these new findings and considers their implications.
AB - Reconstitution of KATP channel activity from coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, as well as the essential roles of Kir6.2 and SUR2 subunits in generating cardiac ventricular KATP. However, despite this extensive body of knowledge, there remain significant holes in our understanding of the physiological role of the cardiac KATP channel, and surprising new findings keep emerging. Recent findings from genetically modified animals include the apparent insensitivity of cardiac sarcolemmal channels to nucleotide levels, and unenvisioned complexities of the subunit make-up of the cardiac channels. This topical review focuses on these new findings and considers their implications.
KW - ATP channel
KW - Diazoxide
KW - Glibenclamide
KW - Kir6.2
KW - Pinacidil
KW - SUR1
KW - mitoK
UR - http://www.scopus.com/inward/record.url?scp=73049111726&partnerID=8YFLogxK
U2 - 10.1016/j.yjmcc.2009.07.002
DO - 10.1016/j.yjmcc.2009.07.002
M3 - Review article
C2 - 19607836
AN - SCOPUS:73049111726
SN - 0022-2828
VL - 48
SP - 71
EP - 75
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
IS - 1
ER -