Cardiac sarcolemmal KATP channels: Latest twists in a questing tale!

Haixia Zhang, Thomas P. Flagg, Colin G. Nichols

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Reconstitution of KATP channel activity from coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, as well as the essential roles of Kir6.2 and SUR2 subunits in generating cardiac ventricular KATP. However, despite this extensive body of knowledge, there remain significant holes in our understanding of the physiological role of the cardiac KATP channel, and surprising new findings keep emerging. Recent findings from genetically modified animals include the apparent insensitivity of cardiac sarcolemmal channels to nucleotide levels, and unenvisioned complexities of the subunit make-up of the cardiac channels. This topical review focuses on these new findings and considers their implications.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalJournal of Molecular and Cellular Cardiology
Volume48
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • ATP channel
  • Diazoxide
  • Glibenclamide
  • Kir6.2
  • Pinacidil
  • SUR1
  • mitoK

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