Cardiac resynchronization therapy acutely improves diastolic function

Alan D. Waggoner, Mitchell N. Faddis, Marye J. Gleva, Lisa De Las Fuentes, Judy Osborn, Sharon Heuerman, Victor G. Davila-Roman

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Background: Invasive studies have shown that cardiac resynchronization therapy (CRT) acutely improves left ventricular (LV) systolic performance and lowers filling pressures in a majority of patients with medically-refractory severe heart failure. Measurements included LV volume, ejection fraction, PWD early (E-wave) and atrial (A-wave) velocities, diastolic filling time (DFT), and DTI early diastolic mitral annular velocity (Em) at the lateral and septal annulus; PWD mitral E-wave/Em and E/FP were calculated to estimate LV filling pressures. Results: Immediately after CRT, LV volumes decreased and LVEF increased significantly. PWD mitral E-wave velocity decreased and E-wave duration and DFT increased significantly; mitral E/FP ratio also decreased significantly, consistent with a decrease in LV filling pressure. Patients with a pre-CRT mitral E/A ratio >1 (n = 20), demonstrated improvements in LV diastolic filling and lower filling pressures whereas those with an E/A ratio ≤1 (n = 21) did not show significant changes in diastolic indices. Conclusions: The acute effects of CRT include echocardiographic evidence of reduced LV volumes and increased LVEF with improved diastolic filling and lower filling pressures; LV relaxation is not significantly altered. The benefits in diastolic function are dependent on the PWD-determined LV filling characteristics prior to CRT.

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalJournal of the American Society of Echocardiography
Issue number3
StatePublished - Mar 2005


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