TY - JOUR
T1 - Cardiac PET/computed tomography applications and cardiovascular outcome
AU - Schindler, Thomas Hellmut
N1 - Funding Information:
Disclosures: Dr Schindler acknowledges all sources of funding as follows: Departmental fund (no. 175470) from Johns Hopkins University, Baltimore, Maryland, USA, and Research grant no. 3200B0-122237 from the Swiss National Science Foundation (SNF; Dr Schindler), with contributions of the Clinical Research Center, University Hospital, and Faculty of Medicine, Geneva and the Louis-Jeantet Foundation; Swiss Heart Foundation; and Gustave and Simone Prévot fund.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Cardiac PET/computed tomography (CT) in conjunction with different blood flow tracers is increasingly applied for the assessment of myocardial perfusion and myocardial flow reserve (MFR) in the detection of coronary artery disease (CAD). The ability of PET/CT to noninvasively determine regional myocardial blood flow at rest and during vasomotor stress allows the calculation of the MFR, which carries important prognostic information in patients with subclinical forms of cardiomyopathy. The measured MFR optimizes the identification and characterization of the extent and severity of CAD burden, and contributes to the flow-limiting effect of single lesions in multivessel CAD.
AB - Cardiac PET/computed tomography (CT) in conjunction with different blood flow tracers is increasingly applied for the assessment of myocardial perfusion and myocardial flow reserve (MFR) in the detection of coronary artery disease (CAD). The ability of PET/CT to noninvasively determine regional myocardial blood flow at rest and during vasomotor stress allows the calculation of the MFR, which carries important prognostic information in patients with subclinical forms of cardiomyopathy. The measured MFR optimizes the identification and characterization of the extent and severity of CAD burden, and contributes to the flow-limiting effect of single lesions in multivessel CAD.
KW - CAD
KW - Coronary circulation
KW - Hibernating myocardium
KW - Myocardial blood flow
KW - Myocardial flow reserve
KW - PET/CT
KW - Prognosis
KW - Sarcoid disease
UR - http://www.scopus.com/inward/record.url?scp=84931956140&partnerID=8YFLogxK
U2 - 10.1016/j.cpet.2015.03.009
DO - 10.1016/j.cpet.2015.03.009
M3 - Review article
C2 - 26099678
AN - SCOPUS:84931956140
SN - 1556-8598
VL - 10
SP - 441
EP - 459
JO - PET Clinics
JF - PET Clinics
IS - 3
ER -