Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that manifests with multiorgan inflammation. Cardiac involvement is common, with manifestation that include pericarditis, myocarditis, conduction defects, valvular disease, and coronary artery disease. In addition to cardiac disease in adults with SLE, the children of women with SLE can develop neonatal lupus by passive transfer of autoantibodies across the placenta. This article describes the cardiac manifestations of SLE and highlights some key unanswered questions about the disease and its pathogenesis.

Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalRheumatic Disease Clinics of North America
Issue number1
StatePublished - Feb 2014


  • Congenital heart block
  • Coronary artery disease
  • Libman-Sacks
  • Myocarditis
  • Neonatal lupus
  • Pericarditis
  • Systemic lupus erythematosus


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