The lymphatic vasculature plays a key role in regulating tissue fluid homeostasis, lipid transport, and immune surveillance throughout the body. Although it has been appreciated that the heart relies on lymphatic vessels to maintain fluid balance and that such balance must be tightly maintained to allow for normal cardiac output, it has only recently come to light that the lymphatic vasculature may serve as a therapeutic target with which to promote optimal healing following myocardial ischemia and infarction. This article reviews the subject of cardiac lymphatic vessels and highlights studies that imply targeting of lymphatic vessel development or transport using vascular endothelial growth factor-C therapy may serve as a promising avenue for future clinical application in the context of ischemic injury.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalJACC: Basic to Translational Science
Issue number4
StatePublished - Aug 2017


  • cardiac lymphatic vessels
  • immune responses
  • interstitial edema
  • lymphangiogenesis
  • myocardial infarction
  • tissue fibrosis
  • vascular endothelial growth factor-C


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