Cardiac KATP channels in health and diseases

Hai Xia Zhang, Jonathan R. Silva, Colin G. Nichols

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Adenosine triphosphate (ATP)-sensitive K+ (KATP) channels were discovered in the heart almost 30 years ago. They are present in multiple tissues and link membrane excitability to the metabolic state of the cell. Under physiological conditions, cardiac KATP channels are predominantly closed, but they may open during exertion, stress, and ischemia. Experimental and modeling studies have shown that activation of sarcolemmal KATP channels causes dramatic action potential shortening in vitro, which can be cardioprotective. Conversely, there is emerging evidence that KATP channel mutations are linked to heart diseases, including congestive heart failure and arrhythmias. The debate regarding the role, and even the very existence, of mitochondrial KATP channels is still ongoing. Filling these knowledge gaps will require further study, and integration of results from basic cellular electrophysiology, to animal models and clinical disease. This chapter will address the current understanding of cardiac KATP channels regarding molecular composition, regulation of channel activity, and physiological and pathophysiological roles.

Original languageEnglish
Title of host publicationBasic Foundations and Primary Electrical Diseases
PublisherSpringer-Verlag London Ltd
Pages259-279
Number of pages21
Volume1
ISBN (Electronic)9781447148814
ISBN (Print)1447148800, 9781447148807
DOIs
StatePublished - Mar 1 2013

Keywords

  • ATP
  • Ischemia
  • Kir6.1
  • Kir6.2
  • Metabolism
  • Potassium channel
  • SUR1
  • SUR2A
  • Sulfonylurea receptor

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