TY - JOUR
T1 - Cardiac ischemia during hemolytic uremic syndrome
AU - Thayu, Meena
AU - Chandler, Wayne L.
AU - Jelacic, Srdjan
AU - Gordon, Carrie A.
AU - Rosenthal, Geoffrey L.
AU - Tarr, Phillip I.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Increased thrombin generation and impaired fibrinolysis during Escherichia coli O157:H7-associated hemolytic uremic syndrome (HUS) plausibly diminish myocardial blood flow, but the frequency of cardiac ischemia during HUS is unknown. We identified a 9-year-old boy with HUS in whom myocardial diastolic dysfunction was demonstrated by echocardiography, who also had elevated serum troponin-I and creatine kinase MB mass. However, eight additional patients with HUS did not have elevated markers of cardiac injury. When present, elevated troponin-I should be considered to represent myocardial injury, and not attributed simply to renal insufficiency. It is possible that myocardial ischemia and secondary arrhythmias account for some sudden deaths that occur during acute HUS.
AB - Increased thrombin generation and impaired fibrinolysis during Escherichia coli O157:H7-associated hemolytic uremic syndrome (HUS) plausibly diminish myocardial blood flow, but the frequency of cardiac ischemia during HUS is unknown. We identified a 9-year-old boy with HUS in whom myocardial diastolic dysfunction was demonstrated by echocardiography, who also had elevated serum troponin-I and creatine kinase MB mass. However, eight additional patients with HUS did not have elevated markers of cardiac injury. When present, elevated troponin-I should be considered to represent myocardial injury, and not attributed simply to renal insufficiency. It is possible that myocardial ischemia and secondary arrhythmias account for some sudden deaths that occur during acute HUS.
KW - Creatine kinase MB mass
KW - Escherichia coli O157:H7
KW - Hemolytic uremic syndrome
KW - Myocardial ischemia
KW - Troponin-I
UR - http://www.scopus.com/inward/record.url?scp=0037821843&partnerID=8YFLogxK
U2 - 10.1007/s00467-002-1039-3
DO - 10.1007/s00467-002-1039-3
M3 - Article
C2 - 12644926
AN - SCOPUS:0037821843
SN - 0931-041X
VL - 18
SP - 286
EP - 289
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 3
ER -