TY - JOUR
T1 - Cardiac Amyloidosis for the Primary Care Provider
T2 - A Practical Review to Promote Earlier Recognition of Disease
AU - Zhang, Kathleen W.
AU - Vallabhaneni, Srilakshmi
AU - Alvarez-Cardona, Jose A.
AU - Krone, Ronald J.
AU - Mitchell, Joshua D.
AU - Lenihan, Daniel J.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/5
Y1 - 2021/5
N2 - Cardiac amyloidosis is increasingly recognized as an underdiagnosed cause of heart failure. Diagnostic delays of up to 3 years from symptom onset may occur, and patients may be evaluated by more than 5 specialists prior to receiving the correct diagnosis. Newly available therapies improve clinical outcomes by preventing amyloid fibril deposition and are usually more effective in early stages of disease, making early diagnosis essential. Better awareness among primary care providers of the clinical presentation and modern treatment landscape is essential to improve timely diagnosis and early treatment of this disease. In this review, we provide practical guidance on the epidemiology, clinical manifestations, diagnostic evaluation, and treatment of transthyretin and light chain cardiac amyloidosis to promote earlier disease recognition among primary care providers.
AB - Cardiac amyloidosis is increasingly recognized as an underdiagnosed cause of heart failure. Diagnostic delays of up to 3 years from symptom onset may occur, and patients may be evaluated by more than 5 specialists prior to receiving the correct diagnosis. Newly available therapies improve clinical outcomes by preventing amyloid fibril deposition and are usually more effective in early stages of disease, making early diagnosis essential. Better awareness among primary care providers of the clinical presentation and modern treatment landscape is essential to improve timely diagnosis and early treatment of this disease. In this review, we provide practical guidance on the epidemiology, clinical manifestations, diagnostic evaluation, and treatment of transthyretin and light chain cardiac amyloidosis to promote earlier disease recognition among primary care providers.
KW - Amyloidosis
KW - Diagnosis, Imaging
KW - Heart failure
UR - http://www.scopus.com/inward/record.url?scp=85100615136&partnerID=8YFLogxK
U2 - 10.1016/j.amjmed.2020.11.031
DO - 10.1016/j.amjmed.2020.11.031
M3 - Review article
C2 - 33444590
AN - SCOPUS:85100615136
SN - 0002-9343
VL - 134
SP - 587
EP - 595
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 5
ER -