In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.
|Journal||Journal of Experimental Medicine|
|State||Published - Oct 3 2022|